Ontology highlight
ABSTRACT:
SUBMITTER: Cavnar MJ
PROVIDER: S-EPMC3865475 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Cavnar Michael J MJ Zeng Shan S Kim Teresa S TS Sorenson Eric C EC Ocuin Lee M LM Balachandran Vinod P VP Seifert Adrian M AM Greer Jonathan B JB Popow Rachel R Crawley Megan H MH Cohen Noah A NA Cohen Noah A NA Green Benjamin L BL Rossi Ferdinand F Besmer Peter P Antonescu Cristina R CR DeMatteo Ronald P RP
The Journal of experimental medicine 20131209 13
Tumor-associated macrophages (TAMs) are a major component of the cancer microenvironment. Modulation of TAMs is under intense investigation because they are thought to be nearly always of the M2 subtype, which supports tumor growth. Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and typically results from an activating mutation in the KIT oncogene. Using a spontaneous mouse model of GIST and 57 freshly procured human GISTs, we discovered that TAMs displayed an M1-like phe ...[more]