Ontology highlight
ABSTRACT:
SUBMITTER: Gao X
PROVIDER: S-EPMC3865483 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Gao Xin X Johnson Kirby D KD Chang Yuan-I YI Boyer Meghan E ME Dewey Colin N CN Zhang Jing J Bresnick Emery H EH
The Journal of experimental medicine 20131202 13
The generation of hematopoietic stem cells (HSCs) from hemogenic endothelium within the aorta, gonad, mesonephros (AGM) region of the mammalian embryo is crucial for development of the adult hematopoietic system. We described a deletion of a Gata2 cis-element (+9.5) that depletes fetal liver HSCs, is lethal at E13-14 of embryogenesis, and is mutated in an immunodeficiency that progresses to myelodysplasia/leukemia. Here, we demonstrate that the +9.5 element enhances Gata2 expression and is requi ...[more]