Dataset Information

Association between interleukin-6 gene polymorphisms and bone mineral density: a meta-analysis.

ABSTRACT: Many studies have examined the association between interleukin-6 (IL-6) gene polymorphisms and bone mineral density (BMD). However, the results remain conflicting. To assess the relationship more precisely, a meta-analysis was performed.The PubMed, Embase, Chinese BioMedical Literature (CBM), Wanfang, and China National Knowledge Infrastructure (CNKI) database were searched for relevant articles published up to March 2013. Weighted mean difference (WMD) and 95% confidence interval (95% CI) were calculated using a fixed-effects or random-effects model.A total of 16 articles with 11,957 subjects were investigated in this meta-analysis. Overall, -634C/G polymorphism was significantly associated with BMD at the femoral neck (WMD, -0.016?g/cm(2); 95% CI, -0.028 to -0.003?g/cm(2)), lumbar spine (WMD, -0.049?g/cm(2); 95% CI, -0.069 to -0.030?g/cm(2)), and whole body (WMD, -0.023?g/cm(2); 95% CI, -0.037 to -0.009?g/cm(2)) for GG versus CC+CG. In subgroup analyses stratified by ethnicity, individuals carrying -634GG genotype had a significantly lower mean BMD at any skeletal site examined, compared with individuals with -634CC or -634CG genotype in Asian populations. For -174G/C polymorphism, the BMD differences between CC+CG and GG genotype were 0.004?g/cm(2) at the distal radius (95% CI, 0.004 to 0.005?g/cm(2)), 0.011?g/cm(2) at the trochanter (95% CI, 0.002 to 0.020?g/cm(2)), and 0.017?g/cm(2) at the Ward's triangle (95% CI, 0.003 to 0.032?g/cm(2)). No significant publication bias was observed in either the -634C/G or -174G/C polymorphism.This suggests that there are modest effects of the -634C/G and -174G/C polymorphisms on BMD. Large-scale and well-designed studies are required to further investigate gene-gene and gene-environment interactions on IL-6 polymorphisms and BMD in various populations.

SUBMITTER: Wang Z

PROVIDER: S-EPMC3865625 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Association between interleukin-6 gene polymorphisms and bone mineral density: a meta-analysis.

Wang Zhao Z Yang Yonghong Y He Minjuan M Wang Ran R Ma Juming J Zhang Yimin Y Zhao Lingyun L Yu Ke K

Genetic testing and molecular biomarkers 20130921 12

<h4>Background</h4>Many studies have examined the association between interleukin-6 (IL-6) gene polymorphisms and bone mineral density (BMD). However, the results remain conflicting. To assess the relationship more precisely, a meta-analysis was performed.<h4>Methods</h4>The PubMed, Embase, Chinese BioMedical Literature (CBM), Wanfang, and China National Knowledge Infrastructure (CNKI) database were searched for relevant articles published up to March 2013. Weighted mean difference (WMD) and 95% ...[more]

PMID: 24053561

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Project description:BACKGROUND: The low-density lipoprotein receptor-related protein 5 gene (LRP5) was identified to be linked to the variation in BMD in high bone mass pedigrees. Subsequent population-based studies of the association between the LRP5 gene and BMD have yielded conflicting results. The present study was aimed at examining the association between LRP5 gene and BMD by using meta-analysis. METHODS: A systematic electronic search of literature was conducted to identify all published studies in English on the association between LRP5 gene and osteoporosis-related phenotypes, including bone mineral density and fracture. BMD data were summarized from individual studies by LRP5 genotype, and a synthesis of data was performed with random-effects meta-analyses. After excluding studies on animal and review papers, there were 19 studies for the synthesis. Among these studies, 10 studies used the rs3736228 (A1330V) polymorphism and reported BMD values. RESULTS: The 10 eligible studies comprised 16,705 individuals, with the majority being women (n = 8444), aged between 18 - 81 years. The overall distribution of genotype frequencies was: AA, 68%, AV and VV, 32%. However, the genotype frequency varied significantly within as well as between ethnic populations. On random-effects meta-analysis, lumbar spine BMD among individuals with the AA genotype was on average 0.018 (95% confidence interval [CI]: 0.012 to 0.023) g/cm2 higher than those with either AV or VV genotype. Similarly, femoral neck BMD among carriers of the AA genotype was 0.011 (95%CI: 0.004 to 0.017) g/cm2 higher than those without the genotype. While there was no significant heterogeneity in the association between the A1330V polymorphism and lumbar spine BMD (p = 0.55), the association was heterogeneous for femoral neck BMD (p = 0.05). The probability that the difference is greater than one standard deviation was 0.34 for femoral neck BMD and 0.54 for lumbar spine BMD. CONCLUSION: These results suggest that there is a modest effect of the A1330V polymorphism on BMD in the general population, and that the modest association may limit its clinical use.

Dataset Information

Association between interleukin-6 gene polymorphisms and bone mineral density: a meta-analysis.

Publications

Association between interleukin-6 gene polymorphisms and bone mineral density: a meta-analysis.

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