Ontology highlight
ABSTRACT:
SUBMITTER: Martinez E
PROVIDER: S-EPMC3865715 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Martinez Emily E Brzostowski Joseph A JA Long Eric O EO Gross Catharina C CC
Journal of immunology (Baltimore, Md. : 1950) 20110404 10
Although the importance of membrane microdomains in receptor-mediated activation of lymphocytes has been established, much less is known about the role of receptor ligand distribution on APC and target cells. Detergent-resistant membrane domains, into which GPI-linked proteins partition, are enriched in cholesterol and glycosphingolipids. ULBP1 is a GPI-linked ligand for natural cytotoxicity receptor NKG2D. To investigate how ULBP1 distribution on target cells affects NKG2D-dependent NK cell act ...[more]