Unknown

Dataset Information

0

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome.

ABSTRACT: Sjögren's syndrome is a common autoimmune disease (affecting ?0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)). We also observed suggestive associations (Pmeta < 5 × 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome.

SUBMITTER: Lessard CJ 

PROVIDER: S-EPMC3867192 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

Lessard Christopher J CJ   Li He H   Adrianto Indra I   Ice John A JA   Rasmussen Astrid A   Grundahl Kiely M KM   Kelly Jennifer A JA   Dozmorov Mikhail G MG   Miceli-Richard Corinne C   Bowman Simon S   Lester Sue S   Eriksson Per P   Eloranta Maija-Leena ML   Brun Johan G JG   Gøransson Lasse G LG   Harboe Erna E   Guthridge Joel M JM   Kaufman Kenneth M KM   Kvarnström Marika M   Jazebi Helmi H   Cunninghame Graham Deborah S DS   Grandits Martha E ME   Nazmul-Hossain Abu N M AN   Patel Ketan K   Adler Adam J AJ   Maier-Moore Jacen S JS   Farris A Darise AD   Brennan Michael T MT   Lessard James A JA   Chodosh James J   Gopalakrishnan Rajaram R   Hefner Kimberly S KS   Houston Glen D GD   Huang Andrew J W AJ   Hughes Pamela J PJ   Lewis David M DM   Radfar Lida L   Rohrer Michael D MD   Stone Donald U DU   Wren Jonathan D JD   Vyse Timothy J TJ   Gaffney Patrick M PM   James Judith A JA   Omdal Roald R   Wahren-Herlenius Marie M   Illei Gabor G GG   Witte Torsten T   Jonsson Roland R   Rischmueller Maureen M   Rönnblom Lars L   Nordmark Gunnel G   Ng Wan-Fai WF   Mariette Xavier X   Anaya Juan-Manuel JM   Rhodus Nelson L NL   Segal Barbara M BM   Scofield R Hal RH   Montgomery Courtney G CG   Harley John B JB   Sivils Kathy L KL  

Nature genetics 20131006 11

Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BL  ...[more]

Similar Datasets

Transcriptomics Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome
2013-10-06 | E-GEOD-51092 | biostudies-arrayexpress
Transcriptomics Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome
2013-10-06 | GSE51092 | GEO
Unknown Dysregulated long non-coding RNA in Sjogren's disease impacts both interferon and adaptive immune responses.
| S-EPMC9717416 | biostudies-literature
Unknown Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells.
| S-EPMC7283543 | biostudies-literature
Unknown Innate and Adaptive Immune Responses in Chronic HCV Infection.
| S-EPMC5625838 | biostudies-other
Unknown Adaptive immune cells temper initial innate responses.
| S-EPMC2435248 | biostudies-literature
Unknown Non-cytotoxic nanoparticles re-educating macrophages achieving both innate and adaptive immune responses for tumor therapy.
| S-EPMC9459000 | biostudies-literature
Unknown NK cells influence both innate and adaptive immune responses after mucosal immunization with antigen and mucosal adjuvant.
| S-EPMC3517975 | biostudies-literature
Unknown The Micro-Immunotherapy Medicine 2LEID Exhibits an Immunostimulant Effect by Boosting Both Innate and Adaptive Immune Responses.
| S-EPMC8744989 | biostudies-literature
Unknown Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus.
| S-EPMC8759664 | biostudies-literature