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Targeting tumor-infiltrating macrophages to combat cancer.

ABSTRACT: Tumor-associated macrophages are one of the major constituents of tumor stroma in many solid tumors and there is compelling preclinical and clinical evidence that macrophages promote cancer initiation and malignant progression. Therefore, these cells represent potential targets for therapeutic benefit. In this review, we will summarize macrophage phenotypic heterogeneity, the current understanding of how tumors take advantage of macrophage plasticity to generate immunosuppression, and how manipulation of specific macrophage populations can be used for therapeutic purposes through translational approaches.

SUBMITTER: Panni RZ

PROVIDER: S-EPMC3867255 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Targeting tumor-infiltrating macrophages to combat cancer.

Panni Roheena Z RZ Linehan David C DC DeNardo David G DG

Immunotherapy 20131001 10

Tumor-associated macrophages are one of the major constituents of tumor stroma in many solid tumors and there is compelling preclinical and clinical evidence that macrophages promote cancer initiation and malignant progression. Therefore, these cells represent potential targets for therapeutic benefit. In this review, we will summarize macrophage phenotypic heterogeneity, the current understanding of how tumors take advantage of macrophage plasticity to generate immunosuppression, and how manipu ...[more]

PMID: 24088077

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