Ontology highlight
ABSTRACT:
SUBMITTER: Rosenkranz SC
PROVIDER: S-EPMC3867334 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Rosenkranz Sina Cathérine SC Geissen Markus M Härter Kristina K Szalay Beata B Ferrer Isidro I Vogel Jana J Smith Stephen S Glatzel Markus M
PloS one 20131218 12
Alzheimer's disease (AD) is the most common form of dementia in the elderly with progressive cognitive decline and memory loss. According to the amyloid-hypothesis, AD is caused by generation and subsequent cerebral deposition of β-amyloid (Aβ). Aβ is generated through sequential cleavage of the transmembrane Amyloid-Precursor-Protein (APP) by two endoproteinases termed beta- and gamma-secretase. Increased APP-expression caused by APP gene dosage effects is a risk factor for the development of A ...[more]