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Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.


ABSTRACT: Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.

SUBMITTER: Lin H 

PROVIDER: S-EPMC3867937 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.

Lin Hao H   Annamalai Thirunavukkarasu T   Bansod Priyanka P   Tse-Dinh Yuk-Ching YC   Sun Dianqing D  

MedChemComm 20131201 12


Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity. ...[more]

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