Ontology highlight
ABSTRACT:
SUBMITTER: Lin H
PROVIDER: S-EPMC3867937 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Lin Hao H Annamalai Thirunavukkarasu T Bansod Priyanka P Tse-Dinh Yuk-Ching YC Sun Dianqing D
MedChemComm 20131201 12
Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity. ...[more]