Ontology highlight
ABSTRACT:
SUBMITTER: Liyanarachchi S
PROVIDER: S-EPMC3868253 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Liyanarachchi Sandya S Wojcicka Anna A Li Wei W Czetwertynska Malgorzata M Stachlewska Elzbieta E Nagy Rebecca R Hoag Kevin K Wen Bernard B Ploski Rafal R Ringel Matthew D MD Kozłowicz-Gudzinska Izabella I Gierlikowski Wojciech W Jazdzewski Krystian K He Huiling H de la Chapelle Albert A
Thyroid : official journal of the American Thyroid Association 20130829 12
<h4>Background</h4>Two recent genome-wide association studies (GWASs) identified five single nucleotide polymorphisms (SNPs; rs965513, rs944289, rs966423, rs2439302, and rs116909374) associated with papillary thyroid carcinoma (PTC). Each variant showed highly significant but moderate to low disease risk. Here we assessed the cumulative risk and predictive value of the five SNPs.<h4>Methods</h4>We genotyped two cohorts of individuals, 747 PTC cases and 1047 controls from Ohio and 1795 PTC cases ...[more]