Aralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells.
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ABSTRACT:
SUBMITTER: Kim MO
PROVIDER: S-EPMC3868379 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
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Aralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells.
Kim Mun Ock MO Lee Sun Hwa SH Seo Jee Hee JH Kim Il Soon IS Han Ah Reum AR Moon Dong Oh DO Cho Sungchan S Cui Long L Kim Jungwoo J Lee Hyun Sun HS
Journal of medicinal food 20131127 12
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first committed step in triacylglycerol (TAG) and phospholipid biosynthesis, and has been considered as one of the drug targets for treating hepatic steatosis, insulin resistance, and other metabolic disorders. The aim of this study was to investigate the GPAT inhibitors from natural products and to evaluate their effects. The methanol extract of Aralia cordata roots showed a strong inhibitory effect on the human GPAT1 activity. A further ...[more]
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