Ontology highlight
ABSTRACT:
SUBMITTER: DeZwaan-McCabe D
PROVIDER: S-EPMC3868529 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
DeZwaan-McCabe Diane D Riordan Jesse D JD Arensdorf Angela M AM Icardi Michael S MS Dupuy Adam J AJ Rutkowski D Thomas DT
PLoS genetics 20131219 12
Viral hepatitis, obesity, and alcoholism all represent major risk factors for hepatocellular carcinoma (HCC). Although these conditions also lead to integrated stress response (ISR) or unfolded protein response (UPR) activation, the extent to which these stress pathways influence the pathogenesis of HCC has not been tested. Here we provide multiple lines of evidence demonstrating that the ISR-regulated transcription factor CHOP promotes liver cancer. We show that CHOP expression is up-regulated ...[more]