Ontology highlight
ABSTRACT:
SUBMITTER: Christophorou N
PROVIDER: S-EPMC3868581 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Christophorou Nicolas N Rubin Thomas T Huynh Jean-René JR
PLoS genetics 20131219 12
Mitosis and meiosis are two distinct cell division programs. During mitosis, sister chromatids separate, whereas during the first meiotic division, homologous chromosomes pair and then segregate from each other. In most organisms, germ cells do both programs sequentially, as they first amplify through mitosis, before switching to meiosis to produce haploid gametes. Here, we show that autosomal chromosomes are unpaired at their centromeres in Drosophila germline stem cells, and become paired duri ...[more]