Ontology highlight
ABSTRACT:
SUBMITTER: Shen K
PROVIDER: S-EPMC3868752 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Shen Kuang K Wang Yaqiang Y Hwang Fu Yu-Hsien YH Zhang Qi Q Feigon Juli J Shan Shu-ou SO
The Journal of biological chemistry 20131022 51
The signal recognition particle (SRP) RNA is a universally conserved and essential component of the SRP that mediates the co-translational targeting of proteins to the correct cellular membrane. During the targeting reaction, two functional ends in the SRP RNA mediate distinct functions. Whereas the RNA tetraloop facilitates initial assembly of two GTPases between the SRP and SRP receptor, this GTPase complex subsequently relocalizes ∼100 Å to the 5',3'-distal end of the RNA, a conformation cruc ...[more]