Ontology highlight
ABSTRACT:
SUBMITTER: Choi WS
PROVIDER: S-EPMC3868924 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Choi Won-Seok WS Rice William J WJ Stokes David L DL Coller Barry S BS
Blood 20131017 26
Integrin αIIbβ3 plays a central role in hemostasis and thrombosis. We provide the first 3-dimensional reconstruction of intact purified αIIbβ3 in a nanodisc lipid bilayer. Unlike previous models, it shows that the ligand-binding head domain is on top, pointing away from the membrane. Moreover, unlike the crystal structure of the recombinant ectodomain, the lower legs are not parallel, straight, and adjacent. Rather, the αIIb lower leg is bent between the calf-1 and calf-2 domains and the β3 Inte ...[more]