Ontology highlight
ABSTRACT:
SUBMITTER: Ishikita H
PROVIDER: S-EPMC3869154 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Ishikita Hiroshi H Saito Keisuke K
Journal of the Royal Society, Interface 20131127 91
In protein environments, proton transfer reactions occur along polar or charged residues and isolated water molecules. These species consist of H-bond networks that serve as proton transfer pathways; therefore, thorough understanding of H-bond energetics is essential when investigating proton transfer reactions in protein environments. When the pKa values (or proton affinity) of the H-bond donor and acceptor moieties are equal, significantly short, symmetric H-bonds can be formed between the two ...[more]