Dataset Information

Controlled synthesis and tunable properties of ultrathin silica nanotubes through spontaneous polycondensation on polyamine fibrils.

ABSTRACT: This paper describes a facile approach to a biomimetic rapid fabrication of ultrathin silica nanotubes with a highly uniform diameter of 10 nm and inner hollow of around 3 nm. The synthesis is carried out through a spontaneous polycondensation of alkoxysilane on polyamine crystalline fibrils that were conveniently produced from the neutralization of a solution of protonated linear polyethyleneimine (LPEI-H(+)) by alkali compounds. A simple mixing the fibrils with alkoxysilane in aqueous solution allowed for the rapid formation of silica to produce LPEI@silica hybrid nanotubes. These 10-nm nanotubes were hierarchically organized in a mat-like morphology with a typical size of 1-2 micrometers. The subsequent removal of organic LPEI via calcination resulted in silica nanotubes that keep this morphology. The morphology, the structure, the pore properties and the formation mechanism of the silica nanotubes were carefully investigated with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller measurements (BET), and X-ray diffraction (XRD). Detailed studies demonstrated that the formation of the nanotubes depends on the molar ratio of [OH]/[CH2CH2NH] during the neutralization as well as on the basicity of the alkali compound and on the concentration of the silica source. The synthesis of silica nanotubes established here could be easily applied to a fabrication on the kilogram scale. Silica nanotubes that were obtained from the calcination of hybrid nanotubes of LPEI@silica in an N2 atmosphere showed a distinct photoluminescence centered at 540 nm with a maximum excitation wavelength of 320 nm. Furthermore, LPEI@silica hybrid nanotubes were applied to create silica-carbon composite nanotubes by alternative adsorption of ionic polymers and subsequent carbonization.

SUBMITTER: Yuan JJ

PROVIDER: S-EPMC3869340 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Controlled synthesis and tunable properties of ultrathin silica nanotubes through spontaneous polycondensation on polyamine fibrils.

Yuan Jian-Jun JJ Zhu Pei-Xin PX Noda Daisuke D Jin Ren-Hua RH

Beilstein journal of nanotechnology 20131125

This paper describes a facile approach to a biomimetic rapid fabrication of ultrathin silica nanotubes with a highly uniform diameter of 10 nm and inner hollow of around 3 nm. The synthesis is carried out through a spontaneous polycondensation of alkoxysilane on polyamine crystalline fibrils that were conveniently produced from the neutralization of a solution of protonated linear polyethyleneimine (LPEI-H(+)) by alkali compounds. A simple mixing the fibrils with alkoxysilane in aqueous solution ...[more]

PMID: 24367748

Similar Datasets

Project description:Bone grafting is one of the commonest surgical procedures, yet all bone substitutes developed so far suffer from specific weaknesses and the search for a bone graft material with ideal physical and biological properties is still ongoing. Calcium phosphate pastes are the most frequently used synthetic bone grafts, yet they (a) often take an impractically long time to set, (b) release the drug content too fast, and (c) do not form pores large enough to accommodate host cells and foster osseointegration. To make up for these deficiencies, we introduced gelatin and silica to pastes composed of 5-15 nm sized hydroxyapatite nanoparticles and yielded a bioresorbable composite that is compact, yet flowing upon injection; that prevents setting at room temperature, but sets promptly, in minutes, at 37 °C; that displays an increase in surface porosity following immersion in physiological fluids; that allows for sustained release of antibiotics; and that sets in a tunable manner and in clinically relevant time windows: 1-3 minutes at its fastest. Timelapse, in situ X-ray diffraction analysis demonstrated that the setting process is accompanied by an increase in crystallinity of the initially amorphous hydroxyapatite, involving no polymorphic phase transitions in its course. Setting time can be tuned by controlling the weight content of gelatin or powder-to-liquid ratio. The release of vancomycin was slow, ~ 8 % after 2 weeks, and unaffected by the gelatin content. While vancomycin-loaded pastes were effective in reducing the concentration of all bacterial species analyzed, the bacteriostatic effects of the antibiotic-free pastes were pronounced against S. liquefaciens and E. coli. S. liquefaciens bacilli underwent beading and filamentation during the treatment, suggesting that the antimicrobial effects are attributable to cell wall disruption by hydroxyapatite nanoparticles. Vancomycin-loaded pastes augmented the activity of the antibiotic against P. aeruginosa and S. liquefaciens, while exhibiting no negative effects against human mesenchymal stem cells. They were also uptaken three times more abundantly than pure hydroxyapatite, indicating the theoretical favorability of their use for intracellular delivery of therapeutics. This selectivity, toxic for bacteria and harmless for primary stem cells, is promising for application as bone grafts for osteomyelitis.

Dataset Information

Controlled synthesis and tunable properties of ultrathin silica nanotubes through spontaneous polycondensation on polyamine fibrils.

Publications

Controlled synthesis and tunable properties of ultrathin silica nanotubes through spontaneous polycondensation on polyamine fibrils.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets