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Synthesis of the spiroketal core of integramycin.

ABSTRACT: A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated.

SUBMITTER: Prusov EV

PROVIDER: S-EPMC3869345 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Synthesis of the spiroketal core of integramycin.

Prusov Evgeny V EV

Beilstein journal of organic chemistry 20131112

A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated. ...[more]

PMID: 24367411

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