Ontology highlight
ABSTRACT:
SUBMITTER: Stein SM
PROVIDER: S-EPMC3869398 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Stein Stacey M SM Tiersten Amy A Hochster Howard S HS Blank Stephanie V SV Pothuri Bhavana B Curtin John J Shapira Ilan I Levinson Benjamin B Ivy Percy P Joseph Benson B Guddati Achuta Kumar AK Muggia Franco F
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20131101 9
<h4>Background</h4>Phase 2 trials suggest that prolonged intravenous (IV) infusion of the topoisomerase 1 inhibitor topotecan may be less toxic than when given by standard IV bolus 5-day administration. Oxaliplatin exhibits efficacy in platinum-pretreated disease and shows preclinical synergy with topoisomerase 1 inhibitors. We sought to determine the efficacy and safety of oxaliplatin plus infusion topotecan in recurrent platinum-pretreated ovarian cancer.<h4>Methods</h4>Patients with recurrent ...[more]