Tendon extracellular matrix damage detection and quantification using automated edge detection analysis.
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ABSTRACT:
SUBMITTER: Ros SJ
PROVIDER: S-EPMC3869460 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Tendon extracellular matrix damage detection and quantification using automated edge detection analysis.
Ros Stephen J SJ Andarawis-Puri Nelly N Flatow Evan L EL
Journal of biomechanics 20130918 16
The accumulation of sub-rupture tendon fatigue damage in the extracellular matrix, particularly of type I collagen fibrils, is thought to contribute to the development of tendinopathy, a chronic and degenerative pathology of tendons. Quantitative assessment of collagen fibril alignment is paramount to understanding the importance of matrix injury to cellular function and remodeling capabilities. This study presents a novel application of edge detection analysis to calculate local collagen fibril ...[more]
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