Ontology highlight
ABSTRACT:
SUBMITTER: Patel A
PROVIDER: S-EPMC3869833 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Biologics : targets & therapy 20131216
The combination of cytotoxic chemotherapy and antiangiogenic agents has become a conventional treatment option for patients with metastatic colorectal cancer. Ziv-aflibercept is a fusion protein which acts as a decoy receptor for vascular endothelial growth factor (VEGF)-A, VEGF-B, and placental growth factor (PlGF); it was approved in combination with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) for the treatment of patients with metastatic colorectal cancer that is resistant to or has ...[more]