Ontology highlight
ABSTRACT:
SUBMITTER: Mentlik James A
PROVIDER: S-EPMC3870292 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Mentlik James Ashley A Cohen Adam D AD Campbell Kerry S KS
Frontiers in immunology 20131223
Natural killer (NK) cells are critical innate immune lymphocytes capable of destroying virally infected or cancerous cells through targeted cytotoxicity and further assisting in the immune response by releasing inflammatory cytokines. NK cells are thought to contribute to the process of tumor killing by certain therapeutic monoclonal antibodies (mAb) by directing antibody-dependent cellular cytotoxicity (ADCC) through FcγRIIIA (CD16). Numerous therapeutic mAb have been developed that target dist ...[more]