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ABSTRACT:
SUBMITTER: Projecto-Garcia J
PROVIDER: S-EPMC3870697 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Projecto-Garcia Joana J Natarajan Chandrasekhar C Moriyama Hideaki H Weber Roy E RE Fago Angela A Cheviron Zachary A ZA Dudley Robert R McGuire Jimmy A JA Witt Christopher C CC Storz Jay F JF
Proceedings of the National Academy of Sciences of the United States of America 20131202 51
Animals that sustain high levels of aerobic activity under hypoxic conditions (e.g., birds that fly at high altitude) face the physiological challenge of jointly optimizing blood-O2 affinity for O2 loading in the pulmonary circulation and O2 unloading in the systemic circulation. At high altitude, this challenge is especially acute for small endotherms like hummingbirds that have exceedingly high mass-specific metabolic rates. Here we report an experimental analysis of hemoglobin (Hb) function i ...[more]