Ontology highlight
ABSTRACT:
SUBMITTER: Monnier P
PROVIDER: S-EPMC3870736 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Monnier Paul P Martinet Clémence C Pontis Julien J Stancheva Irina I Ait-Si-Ali Slimane S Dandolo Luisa L
Proceedings of the National Academy of Sciences of the United States of America 20131202 51
The H19 gene controls the expression of several genes within the Imprinted Gene Network (IGN), involved in growth control of the embryo. However, the underlying mechanisms of this control remain elusive. Here, we identified the methyl-CpG-binding domain protein 1 MBD1 as a physical and functional partner of the H19 long noncoding RNA (lncRNA). The H19 lncRNA-MBD1 complex is required for the control of five genes of the IGN. For three of these genes--Igf2 (insulin-like growth factor 2), Slc38a4 ( ...[more]