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ABSTRACT:
SUBMITTER: Morcos F
PROVIDER: S-EPMC3870752 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Morcos Faruck F Jana Biman B Hwa Terence T Onuchic José N JN
Proceedings of the National Academy of Sciences of the United States of America 20131202 51
A long-standing problem in molecular biology is the determination of a complete functional conformational landscape of proteins. This includes not only proteins' native structures, but also all their respective functional states, including functionally important intermediates. Here, we reveal a signature of functionally important states in several protein families, using direct coupling analysis, which detects residue pair coevolution of protein sequence composition. This signature is exploited ...[more]