Ontology highlight
ABSTRACT:
SUBMITTER: Cassataro D
PROVIDER: S-EPMC3870771 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cassataro Daniela D Bergfeldt Daniella D Malekian Cariz C Van Snellenberg Jared X JX Thanos Panayotis K PK Fishell Gord G Sjulson Lucas L
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20130801 2
Bilateral stereotactic lesioning of the nucleus accumbens (NAc) core reduces relapse rates in alcohol-dependent patients but may cause irreversible cognitive deficits. Deep brain stimulation has similar effects but requires costly implanted hardware and regular surgical maintenance. Therefore, there is considerable interest in refining these approaches to develop reversible, minimally invasive treatments for alcohol dependence. Toward this end, we evaluated the feasibility of a reverse pharmacog ...[more]