Ontology highlight
ABSTRACT:
SUBMITTER: McCullough CR
PROVIDER: S-EPMC3870883 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
McCullough Christopher R CR Pullela Phani Kumar PK Im Sang-Choul SC Waskell Lucy L Sem Daniel S DS
Journal of biomolecular NMR 20090206 3
The cytochromes P450 (CYPs) play a central role in many biologically important oxidation reactions, including the metabolism of drugs and other xenobiotic compounds. Because they are often assayed as both drug targets and anti-targets, any tools that provide: (a) confirmation of active site binding and (b) structural data, would be of great utility, especially if data could be obtained in reasonably high throughput. To this end, we have developed an analog of the promiscuous heme ligand, cyanide ...[more]