Ontology highlight
ABSTRACT:
SUBMITTER: Wang PH
PROVIDER: S-EPMC3871164 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wang Pei-Hui PH Wan Ding-Hui DH Chen Yong-Gui YG Weng Shao-Ping SP Yu Xiao-Qiang XQ He Jian-Guo JG
PloS one 20131223 12
Apoptosis plays an important role in white spot syndrome virus (WSSV) pathogenesis, and caspases are central players in apoptosis. Here, we cloned four novel caspases (Lvcaspase2-5) from the Pacific white shrimp Litopenaeus vannamei, and investigated their potential roles in WSSV replication using dsRNA-mediated gene silencing. Lvcaspase2-5 have the typical domain structure of caspase family proteins, with the conserved consensus motifs p20 and p10. Lvcaspase2 and Lvcaspase5 were highly expresse ...[more]