Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC3871176 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Zhang Fuming F Moniz Heather A HA Walcott Benjamin B Moremen Kelley W KW Linhardt Robert J RJ Wang Lianchun L
Biochimie 20130828 12
Roundabout 1 (Robo1) is the cognate receptor for secreted axon guidance molecule, Slits, which function to direct cellular migration during neuronal development and angiogenesis. The Slit2-Robo1 signaling is modulated by heparan sulfate, a sulfated linear polysaccharide that is abundantly expressed on the cell surface and in the extracellular matrix. Biochemical studies have further shown that heparan sulfate binds to both Slit2 and Robo1 facilitating the ligand-receptor interaction. The structu ...[more]