Ontology highlight
ABSTRACT:
SUBMITTER: Orr MT
PROVIDER: S-EPMC3871206 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Orr Mark T MT Fox Christopher B CB Baldwin Susan L SL Sivananthan Sandra J SJ Lucas Elyse E Lin Susan S Phan Tony T Moon James J JJ Vedvick Thomas S TS Reed Steven G SG Coler Rhea N RN
Journal of controlled release : official journal of the Controlled Release Society 20130809 1
One third of the world is infected with Mycobacterium tuberculosis (Mtb) with eight million new cases of active tuberculosis (TB) each year. Development of a new vaccine to augment or replace the only approved TB vaccine, BCG, is needed to control this disease. Mtb infection is primarily controlled by TH1 cells through the production of IFN-γ and TNF which activate infected macrophages to kill the bacterium. Here we examine an array of adjuvant formulations containing the TLR4 agonist GLA to ide ...[more]