Ontology highlight
ABSTRACT:
SUBMITTER: Cobanoglu MC
PROVIDER: S-EPMC3871285 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Cobanoglu Murat Can MC Liu Chang C Hu Feizhuo F Oltvai Zoltán N ZN Bahar Ivet I
Journal of chemical information and modeling 20131210 12
Quantitative analysis of known drug-target interactions emerged in recent years as a useful approach for drug repurposing and assessing side effects. In the present study, we present a method that uses probabilistic matrix factorization (PMF) for this purpose, which is particularly useful for analyzing large interaction networks. DrugBank drugs clustered based on PMF latent variables show phenotypic similarity even in the absence of 3D shape similarity. Benchmarking computations show that the me ...[more]