Repeated functional convergent effects of NaV1.7 on acid insensitivity in hibernating mammals.
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ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC3871328 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Repeated functional convergent effects of NaV1.7 on acid insensitivity in hibernating mammals.
Liu Zhen Z Wang Wei W Zhang Tong-Zuo TZ Li Gong-Hua GH He Kai K Huang Jing-Fei JF Jiang Xue-Long XL Murphy Robert W RW Shi Peng P
Proceedings. Biological sciences 20131218 1776
Hibernating mammals need to be insensitive to acid in order to cope with conditions of high CO2; however, the molecular basis of acid tolerance remains largely unknown. The African naked mole-rat (Heterocephalus glaber) and hibernating mammals share similar environments and physiological features. In the naked mole-rat, acid insensitivity has been shown to be conferred by the functional motif of the sodium ion channel NaV1.7. There is now an opportunity to evaluate acid insensitivity in other ta ...[more]
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