Ontology highlight
ABSTRACT:
SUBMITTER: Rey GU
PROVIDER: S-EPMC3871585 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Rey Gertrud U GU Miao Congrong C Caidi Hayat H Trivedi Suvang U SU Harcourt Jennifer L JL Tripp Ralph A RA Anderson Larry J LJ Haynes Lia M LM
PloS one 20131223 12
Respiratory syncytial virus (RSV) is a high priority target for vaccine development. One concern in RSV vaccine development is that a non-live virus vaccine would predispose for enhanced disease similar to that seen with the formalin inactivated RSV (FI-RSV) vaccine. Since a mAb specific to RSV G protein can reduce pulmonary inflammation and eosinophilia seen after RSV infection of FI-RSV vaccinated mice, we hypothesized that RSV G peptides that induce antibodies with similar reactivity may limi ...[more]