Dataset Information
Positive association between GCKR rs780093 polymorphism and coronary heart disease in the aged Han Chinese.
Ontology highlight
ABSTRACT: Objective
Previous studies have confirmed that GCKR rs780093 polymorphism is associated with triglyceride (TG), a known risk factor of coronary heart disease (CHD). The goal of our study is to explore the association of GCKR rs780093 polymorphism with CHD in Han Chinese population.Methods and results
A total of 568 CHD cases and 494 non-CHD controls were enrolled in the current case-control study. Genotyping was done using melting temperature shift (Tm-shift) approach. Our results also showed that GCKR rs780093 polymorphism was significantly associated with TG level (P = 0.0016). Although there was no significant association between cases and controls (P > 0.05), a breakdown analysis by age yielded a significant association of GCKR rs780093 polymorphism with CHD in individuals aged 65 and older (genotype: χ(2) = 6.86; df = 2; P = 0.03; allele: χ(2) = 4.11; df = 1; P = 0.04).Conclusion
Our findings confirmed the contribution of GCKR rs780093 polymorphism to TG metabolism and demonstrated GCKR rs780093 as a risk factor of CHD in individuals aged 65 and older.
SUBMITTER: Lian J
PROVIDER: S-EPMC3871702 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Positive association between GCKR rs780093 polymorphism and coronary heart disease in the aged Han Chinese.
Disease markers 20131209 6
<h4>Objective</h4>Previous studies have confirmed that GCKR rs780093 polymorphism is associated with triglyceride (TG), a known risk factor of coronary heart disease (CHD). The goal of our study is to explore the association of GCKR rs780093 polymorphism with CHD in Han Chinese population.<h4>Methods and results</h4>A total of 568 CHD cases and 494 non-CHD controls were enrolled in the current case-control study. Genotyping was done using melting temperature shift (Tm-shift) approach. Our result ...[more]
