Lowering of blood pressure during chronic suppression of central sympathetic outflow: insight from computer simulations.

ABSTRACT: 1. Chronic electrical stimulation of the carotid sinuses has provided unique insight into the mechanisms that cause sustained reductions in blood pressure during chronic suppression of central sympathetic outflow. 2. Because renal denervation does not abolish the sustained fall in arterial pressure in response to baroreflex activation, this observation has seemingly challenged the concept that the kidneys play a critical role in the long-term control of arterial pressure during chronic changes in sympathetic activity. The aim of the present study was to use computer simulations to provide a more comprehensive understanding of physiological mechanisms that mediate sustained reductions in arterial pressure during prolonged baroreflex-mediated suppression of central sympathetic outflow. 3. Ph

SUBMITTER: Iliescu R 

PROVIDER: S-EPMC3872032 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature