Ontology highlight
ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC3872143 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Zhao Xiangbo X Hersleth Hans-Petter HP Zhu Janan J Andersson K Kristoffer KK Magliozzo Richard S RS
Chemical communications (Cambridge, England) 20131201 99
Peroxidatic activation of the anti-tuberculosis pro-drug isoniazid by Mycobacterium tuberculosis catalase-peroxidase (KatG) is regulated by gating residues of a heme access channel. The steric restriction at the bottleneck of this channel is alleviated by replacement of residue Asp137 with Ser, according to crystallographic and kinetic studies. ...[more]