Ontology highlight
ABSTRACT:
SUBMITTER: Shaffer PL
PROVIDER: S-EPMC387321 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Shaffer Paul L PL Jivan Arif A Dollins D Eric DE Claessens Frank F Gewirth Daniel T DT
Proceedings of the National Academy of Sciences of the United States of America 20040322 14
Steroid receptors bind as dimers to a degenerate set of response elements containing inverted repeats of a hexameric half-site separated by 3 bp of spacer (IR3). Naturally occurring selective androgen response elements have recently been identified that resemble direct repeats of the hexameric half-site (ADR3). The 3D crystal structure of the androgen receptor (AR) DNA-binding domain bound to a selective ADR3 reveals an unexpected head-to-head arrangement of the two protomers rather than the exp ...[more]