Ontology highlight
ABSTRACT:
SUBMITTER: Narayanan R
PROVIDER: S-EPMC3873281 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Narayanan Ramesh R Yepuru Muralimohan M Coss Christopher C CC Wu Zhongzhi Z Bauler Matthew N MN Barrett Christina M CM Mohler Michael L ML Wang Yun Y Kim Juhyun J Snyder Linda M LM He Yali Y Levy Nelson N Miller Duane D DD Dalton James T JT
PloS one 20131226 12
Receptor tyrosine kinases (RTKs), in response to their growth factor ligands, phosphorylate and activate downstream signals important for physiological development and pathological transformation. Increased expression, activating mutations and rearrangement fusions of RTKs lead to cancer, inflammation, pain, neurodegenerative diseases, and other disorders. Activation or over-expression of ALK, ROS1, TRK (A, B, and C), and RET are associated with oncogenic phenotypes of their respective tissues, ...[more]