Ontology highlight
ABSTRACT:
SUBMITTER: Lieberman-Lazarovich M
PROVIDER: S-EPMC3873452 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lieberman-Lazarovich Michal M Melamed-Bessudo Cathy C de Pater Sylvia S Levy Avraham A AA
PloS one 20131226 12
Gene Targeting (GT) is the integration of an introduced vector into a specific chromosomal site, via homologous recombination. It is considered an effective tool for precise genome editing, with far-reaching implications in biological research and biotechnology, and is widely used in mice, with the potential of becoming routine in many species. Nevertheless, the epigenetic status of the targeted allele remains largely unexplored. Using GT-modified lines of the model plant Arabidopsis thaliana, w ...[more]