Ontology highlight
ABSTRACT:
SUBMITTER: Kashuba VI
PROVIDER: S-EPMC387347 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Kashuba Vladimir I VI Li Jingfeng J Wang Fuli F Senchenko Vera N VN Protopopov Alexey A Malyukova Alena A Kutsenko Alexey S AS Kadyrova Elena E Zabarovska Veronika I VI Muravenko Olga V OV Zelenin Alexander V AV Kisselev Lev L LL Kuzmin Igor I Minna John D JD Winberg Gösta G Ernberg Ingemar I Braga Eleonora E Lerman Michael I MI Klein George G Zabarovsky Eugene R ER
Proceedings of the National Academy of Sciences of the United States of America 20040329 14
Chromosome 3p21.3 region is frequently (>90%) deleted in lung and other major human carcinomas. We subdivided 3p21.3 into LUCA and AP20 subregions and discovered frequent homozygous deletions (10-18%) in both subregions. This finding strongly implies that they harbor multiple tumor suppressor genes involved in the origin and/or development of major epithelial cancers. In this study, we performed an initial analysis of RBSP3/HYA22, a candidate tumor suppressor genes located in the AP20 region. Tw ...[more]