Ontology highlight
ABSTRACT:
SUBMITTER: Peiris PM
PROVIDER: S-EPMC3873646 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Journal of controlled release : official journal of the Controlled Release Society 20131102
While potent cytotoxic agents are available to oncologists, the clinical utility of these agents is limited due to their non-specific distribution in the body and toxicity to normal tissues leading to use of suboptimal doses for eradication of metastatic disease. Furthermore, treatment of micrometastases is impeded by several biobarriers, including their small size and high dispersion to organs, making them nearly inaccessible to drugs. To circumvent these limitations in treating metastatic dise ...[more]