Ontology highlight
ABSTRACT:
SUBMITTER: Schreiber S
PROVIDER: S-EPMC387367 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Schreiber Sören S Konradt Manuela M Groll Claudia C Scheid Peter P Hanauer Guido G Werling Hans-Otto HO Josenhans Christine C Suerbaum Sebastian S
Proceedings of the National Academy of Sciences of the United States of America 20040325 14
The highly motile human pathogen Helicobacter pylori lives deep in the gastric mucus layer. To identify which chemical gradient guides the bacteria within the mucus layer, combinations of luminal perfusion, dialysis, and ventilation were used to modify or invert transmucus gradients in anaesthetized Helicobacter-infected mice and Mongolian gerbils. Neither changes in lumen or arterial pH nor inversion of bicarbonate/CO2 or urea/ammonium gradients disturbed Helicobacter orientation. However, elim ...[more]