Tyrosol is a quorum-sensing molecule in Candida albicans.
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ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC387371 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Publications
Tyrosol is a quorum-sensing molecule in Candida albicans.
Chen Hao H Fujita Masaki M Feng Qinghua Q Clardy Jon J Fink Gerald R GR
Proceedings of the National Academy of Sciences of the United States of America 20040329 14
The human fungal pathogen Candida albicans shows a significant lag in growth when diluted into fresh minimal medium. This lag is abolished by the addition of conditioned medium from a high-density culture. The active component of conditioned medium is tyrosol, which is released into the medium continuously during growth. Under conditions permissive for germ-tube formation, tyrosol stimulates the formation of these filamentous protrusions. Because germ-tube formation is inhibited by farnesol, ano ...[more]
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