Ontology highlight
ABSTRACT:
SUBMITTER: Takeda S
PROVIDER: S-EPMC387418 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Takeda Shin S Tadele Zerihun Z Hofmann Ingo I Probst Aline V AV Angelis Karel J KJ Kaya Hidetaka H Araki Takashi T Mengiste Tesfaye T Mittelsten Scheid Ortrun O Shibahara Kei-ichi K Scheel Dierk D Paszkowski Jerzy J
Genes & development 20040401 7
DNA repair associated with DNA replication is important for the conservation of genomic sequence information, whereas reconstitution of chromatin after replication sustains epigenetic information. We have isolated and characterized mutations in the BRU1 gene of Arabidopsis that suggest a novel link between these underlying maintenance mechanisms. Bru1 plants are highly sensitive to genotoxic stress and show stochastic release of transcriptional gene silencing. They also show increased intrachrom ...[more]