Ontology highlight
ABSTRACT:
SUBMITTER: Akdemir KC
PROVIDER: S-EPMC3874181 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Akdemir Kadir C KC Jain Abhinav K AK Allton Kendra K Aronow Bruce B Xu Xueping X Cooney Austin J AJ Li Wei W Barton Michelle Craig MC
Nucleic acids research 20130927 1
How tumor suppressor p53 selectively responds to specific signals, especially in normal cells, is poorly understood. We performed genome-wide profiling of p53 chromatin interactions and target gene expression in human embryonic stem cells (hESCs) in response to early differentiation, induced by retinoic acid, versus DNA damage, caused by adriamycin. Most p53-binding sites are unique to each state and define stimulus-specific p53 responses in hESCs. Differentiation-activated p53 targets include m ...[more]