Ontology highlight
ABSTRACT:
SUBMITTER: Kulkarni RA
PROVIDER: S-EPMC3874405 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Kulkarni Rhushikesh A RA Vellore Nadeem A NA Bliss Matthew R MR Stanford Stephanie M SM Falk Matthew D MD Bottini Nunzio N Baron Riccardo R Barrios Amy M AM
Chembiochem : a European journal of chemical biology 20130816 13
Assay design is an important variable that influences the outcome of an inhibitor screen. Here, we have investigated the hypothesis that protein tyrosine phosphatase inhibitors with improved biological activity could be identified from a screen by using a biologically relevant peptide substrate, rather than traditional phosphotyrosine mimetic substrates. A 2000-member library of drugs and drug-like compounds was screened for inhibitors of lymphoid tyrosine phosphatase (LYP) by using both a pepti ...[more]