Ontology highlight
ABSTRACT:
SUBMITTER: Weimer RM
PROVIDER: S-EPMC3874415 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Weimer Robby M RM Richmond Janet E JE Davis Warren S WS Hadwiger Gayla G Nonet Michael L ML Jorgensen Erik M EM
Nature neuroscience 20030914 10
Sec1-related proteins function in most, if not all, membrane trafficking pathways in eukaryotic cells. The Sec1-related protein required in neurons for synaptic vesicle exocytosis is UNC-18. Several models for UNC-18 function during vesicle exocytosis are under consideration. We have tested these models by characterizing unc-18 mutants of the nematode Caenorhabditis elegans. In the absence of UNC-18, the size of the readily releasable pool is severely reduced. Our results show that the near abse ...[more]