Ontology highlight
ABSTRACT:
SUBMITTER: Sette G
PROVIDER: S-EPMC3874650 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Sette Giovanni G Fecchi Katia K Salvati Valentina V Lotti Fiorenza F Pilozzi Emanuela E Duranti Enrico E Biffoni Mauro M Pagliuca Alfredo A Martinetti Daniela D Memeo Lorenzo L Milella Michele M De Maria Ruggero R Eramo Adriana A
Journal of experimental & clinical cancer research : CR 20131116
One of the key oncogenic pathways involved in melanoma aggressiveness, development and progression is the RAS/BRAF/MEK pathway, whose alterations are found in most patients. These molecular anomalies are promising targets for more effective anti-cancer therapies. Some Mek inhibitors showed promising antitumor activity, although schedules and doses associated with low systemic toxicity need to be defined. In addition, it is now accepted that cancers can arise from and be maintained by the cancer ...[more]