Ontology highlight
ABSTRACT:
SUBMITTER: Santi A
PROVIDER: S-EPMC3874735 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Santi Alice A Caselli Anna A Paoli Paolo P Corti Denise D Camici Guido G Pieraccini Giuseppe G Taddei Maria Letizia ML Serni Sergio S Chiarugi Paola P Cirri Paolo P
Cell communication and signaling : CCS 20131029
Solid tumors are composed of both cancer cells and various types of accessory cells, mainly fibroblasts, that collectively compose the so called tumor-microenvironment. Cancer-associated fibroblasts have been described to actively participate in cancer progression by establishing a cytokine-mediated as well as metabolic crosstalk with cancer cells. In the present paper we show that activated human fibroblasts are able to boost tumor cells proliferation and that this effect is greatly dependent o ...[more]