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Hospital-based surveillance for rotavirus gastroenteritis using molecular testing and immunoassay during the 2011 season in Botswana.

ABSTRACT: We describe rotavirus testing and clinical characteristics for children admitted with acute gastroenteritis during Botswana's 2011 rotavirus season. The rotavirus season extended from June to October with rotavirus-specific case fatality being 2.8%. Using molecular testing as reference, the immunochromatographic test had a sensitivity of 76.5% and specificity of 68.0%. Rotavirus vaccine may significantly reduce childhood morbidity and mortality in Botswana.

SUBMITTER: Welch H 

PROVIDER: S-EPMC3874800 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Hospital-based surveillance for rotavirus gastroenteritis using molecular testing and immunoassay during the 2011 season in Botswana.

Welch Henry H   Steenhoff Andrew P AP   Chakalisa Unoda U   Arscott-Mills Tonya T   Mazhani Loeto L   Mokomane Margaret M   Foster-Fabiano Sara S   Wirth Kathleen E KE   Skinn Andrew A   Pernica Jeffrey M JM   Smieja Marek M   Goldfarb David M DM  

The Pediatric infectious disease journal 20130501 5

We describe rotavirus testing and clinical characteristics for children admitted with acute gastroenteritis during Botswana's 2011 rotavirus season. The rotavirus season extended from June to October with rotavirus-specific case fatality being 2.8%. Using molecular testing as reference, the immunochromatographic test had a sensitivity of 76.5% and specificity of 68.0%. Rotavirus vaccine may significantly reduce childhood morbidity and mortality in Botswana. ...[more]

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