Ontology highlight
ABSTRACT:
SUBMITTER: Gupta P
PROVIDER: S-EPMC3874817 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Gupta Pulkit P Kannan Krishna K Mankin Alexander S AS Vázquez-Laslop Nora N
Molecular cell 20131114 5
The expression of many genes is controlled by upstream ORFs (uORFs). Typically, the progression of the ribosome through a regulatory uORF, which depends on the physiological state of the cell, influences the expression of the downstream gene. In the classic mechanism of induction of macrolide resistance genes, antibiotics promote translation arrest within the uORF, and the static ribosome induces a conformational change in mRNA, resulting in the activation of translation of the resistance cistro ...[more]